Niche construction refers to the activities of organisms that bring about changes in their environments, many of which are evolutionarily and ecologically consequential. Advocates of niche construction theory (NCT) believe that standard evolutionary theory fails to recognize the full importance of niche construction, and consequently propose a novel view of evolution, in which niche construction and its legacy over time (ecological inheritance) are described as evolutionary processes, equivalent in importance to natural selection. Here, we subject NCT to critical evaluation, in (...) the form of a collaboration between one prominent advocate of NCT, and a team of skeptics. We discuss whether niche construction is an evolutionary process, whether NCT obscures or clarifies how natural selection leads to organismal adaptation, and whether niche construction and natural selection are of equivalent explanatory importance. We also consider whether the literature that promotes NCT overstates the significance of niche construction, whether it is internally coherent, and whether it accurately portrays standard evolutionary theory. Our disagreements reflect a wider dispute within evolutionary theory over whether the neo-Darwinian synthesis is in need of reformulation, as well as different usages of some key terms (e.g., evolutionary process). (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

В монографии опубликованы статьи преподавателей, аспирантов кафедры философии ВГПУ и других вузов, посвященные актуальным проблемам философии науки, философским проблемам конкретно-научного знания.

In the late 1810s and 1820s the Edinburgh phrenologists were largely concerned with trying to establish phrenology as the true science of mind. They challenged the accepted theories about the nature of mind and the brain; in turn, phrenology was attacked by the proponents of Scottish common-sense philosophy and by some medical men. The ensuing debate, which is discussed as an example of conflict between incommensurable world-views, involved a wide range of contentious theological, philosophical, scientific and methodological issues.

G. N. A. Vesey; XI—Berkeley and the Man Born Blind, Proceedings of the Aristotelian Society, Volume 61, Issue 1, 1 June 1961, Pages 189–206, https://doi.org/10.

If there is one question which stands forth pre-eminently from among the many problems with which physical science bristles, it is that of the ontological status of the world which physics is exploring. What is reality in the eyes of science, and what are we to understand the physicist to mean when he refers to the “real world”? Can we agree with him when he assures us that physical science represents a progress towards pure truth? There seems to be a (...) certain reluctance on the part of twentieth-century physicists to face the ontological question which I think their colleagues of the nineteenth century did not share to the same extent. (shrink)

‘Let us not forget this: when “I raise my arm”;, my arm goes up. And the problem arises: what is left over if I subtract the fact that my arm goes up from that fact that I raise my arm?’.

Originally published in 1951, Homo Faberis an examination of the scientific outlook on human mental evolution through the lens of parapsychology. The book aims to undermine what its terms, the 'scientific outlook' examining the human interpretation of the world, and the preconceived scientific concepts that reality does not extend beyond the realm that our senses reveal. The book expands upon this and moves to examine the broader human understanding of the entire cosmos, challenging the scientific conception that this can be (...) grasped in principal by human intellect, arising from the chance combination of material particles. The book argues that the scientific outlook prevents humans from discovering in the Universe the meaning and purpose which are everywhere to be found if sought in the appropriate contemplative states of mind. This book provides a unique take on the examination of human psychology and the evolution of the brain from an alternative scientific stance. It will be of interest to anthropologists, historians and psychologists alike. will be of interest to anthropologists, historians and psychologists alike. (shrink)

Berkeley's "new theory of vision" and, In particular, His sensationalist solution to the problem of judging distance and magnitude were discussed by many eighteenth-Century authors who faced a variety of problem situations. More specifically, Berkeley's theory fed into the debate over whether the phenomena of vision were susceptible to mathematical analysis or were experientially determined. In this paper a variety of responses to berkeley are examined, Concluding with thomas reid's attempt to distinguish physical optics (which can be analyzed geometrically) from (...) the psychology of vision (in which experience plays a major role). (shrink)